HCID 18621154, compound → HCID 18621150, compound

Participants

Reaction Steps

To a solution of N-(benzyloxycarbonyl)-2-[4-(t-butyldimethyl siloxy)-1-piperidyl] ethylamine (1.47 g) in tetrahydrofuran (37 ml), there was added 20% palladium hydroxide-on-carbon (100 mg). The resulting mixture was stirred over 2 days under a hydrogen gas atmosphere. The mixture was filtered through celite to remove the palladium hydroxide-on-carbon and the resulting filtrate was concentrated under reduced pressure. The resulting oily product was purified through the silica gel column chromatography to thus give the title compound (Reference Compound 5-1, 0.28 g).

Provenance & Evidence