Oxygen → Ethyl 3-amino-2-methoxy-6-methylpyridine-4-carboxylate

Participants

Reaction Steps

To an oxygen free solution of the nitro ester 1-2 from step B (2.5 g, 10.4 mmol) in 50 mL of EtOAc was added 520 mg of 10% Pd on charcoal. Hydrogen gas was added and the reaction mixture was stirred for 17 h. The solution was filtered through a pad of Celite, concentrated and chromatographed (2:3 EtOAc/Hexane) to give the desired amine 9-3 as a white solid.

Provenance & Evidence