(1-Acetylpiperidin-4-yl)acetic acid → HCID 18620877, compound

HRID 1861709Notes

Reaction equation

HRID 1861709 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11]([OH:13])=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH:14]([N:16]1[CH2:22][CH2:21][C:20]2[CH:23]=[CH:24][CH:25]=[CH:26][C:19]=2[CH2:18][CH2:17]1)=[O:15]>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([CH2:10][C:11]([C:25]2[CH:24]=[CH:23][C:20]3[CH2:21][CH2:22][N:16]([CH:14]=[O:15])[CH2:17][CH2:18][C:19]=3[CH:26]=2)=[O:13])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 10442408(1-Acetylpiperidin-4-yl)acetic acidHCID 11073927HCID 11073927, compound

Product 1

HCID 18620877HCID 18620877, compound

Procedure

Using (1-acetyl-4-piperidinyl)acetic acid and 3-formyl-2,3,4,5-tetrahydro-1H-3-benzazepine as obtained in Reference Example 2, the procedure of Example 23-1) was similarly repeated to provide 2-(1-acetyl-4-piperidinyl)-1-(3-formyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-ethanone as light-yellow oil.

Workup

  1. customas obtained in Reference Example 2

Sources & evidence

ORD record
ord-e5587ee5f3a24995b6bc223baa351e75
Source dataset
uspto-grants-2003_03
Patent number
US06534496B1

Reaction notes

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