1-(Bromomethyl)-3-chlorobenzene → HCID 18620589, compound

HRID 1861713Notes

Reaction equation

HRID 1861713 reaction equation
[ClH:1].Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:17][CH2:16][CH2:15][C:14]3[CH:18]=[CH:19][C:20]([C:22](=[O:31])[CH2:23][CH2:24][CH:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)=[CH:21][C:13]=3[CH2:12]2)=[CH:6][CH:5]=1.[Cl:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][CH:40]=1)[CH2:36]Br>>[ClH:32].[ClH:1].[Cl:32][C:33]1[CH:34]=[C:35]([CH2:36][N:28]2[CH2:27][CH2:26][CH:25]([CH2:24][CH2:23][C:22]([C:20]3[CH:19]=[CH:18][C:14]4[CH2:15][CH2:16][CH2:17][N:11]([CH2:10][C:7]5[CH:6]=[CH:5][C:4]([F:3])=[CH:9][CH:8]=5)[CH2:12][C:13]=4[CH:21]=3)=[O:31])[CH2:30][CH2:29]2)[CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 18621056HCID 18621056, compound

Product 1

HCID 18620589HCID 18620589, compound

Procedure

Using 1-[2-[(4-fluorophenyl)methyl]-2,3,4,5-tetrahydro-1H-2-benzazepin-8-yl]-3-(4-piperidinyl)-1-propanone(free base) obtained in Example 211, and 3-chlorobenzyl bromide, the procedure of Example 51-3 was otherewise repeated to provide the title compound as colorless amorphous powders.

Sources & evidence

ORD record
ord-70de32910e384bfaa247f4bbd2508da7
Source dataset
uspto-grants-2003_03
Patent number
US06534496B1

Reaction notes

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