1-(Bromomethyl)-2-(trifluoromethyl)benzene → HCID 18620905, compound

HRID 1861715Notes

Reaction equation

HRID 1861715 reaction equation
[ClH:1].Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:17][CH2:16][CH2:15][C:14]3[CH:18]=[CH:19][C:20]([C:22](=[O:31])[CH2:23][CH2:24][CH:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)=[CH:21][C:13]=3[CH2:12]2)=[CH:6][CH:5]=1.[F:32][C:33]([F:43])([F:42])[C:34]1[CH:41]=[CH:40][CH:39]=[CH:38][C:35]=1[CH2:36]Br>>[ClH:1].[ClH:1].[F:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][N:11]2[CH2:17][CH2:16][CH2:15][C:14]3[CH:18]=[CH:19][C:20]([C:22](=[O:31])[CH2:23][CH2:24][CH:25]4[CH2:26][CH2:27][N:28]([CH2:36][C:35]5[CH:38]=[CH:39][CH:40]=[CH:41][C:34]=5[C:33]([F:32])([F:42])[F:43])[CH2:29][CH2:30]4)=[CH:21][C:13]=3[CH2:12]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 18621056HCID 18621056, compound

Product 1

HCID 18620905HCID 18620905, compound

Procedure

Using 1-[2-[(4-fluorophenyl)methyl]-2,3,4,5-tetrahydro-1H-2-benzazepin-8-yl]-3-(4-piperidinyl)-1-propanone(free base) obtained in Example 211, and 2-(trifluoromethyl)benzyl bromide, the procedure of Example 51-3 was otherewise repeated to provide the title compound as colorless amorphous powders.

Sources & evidence

ORD record
ord-6e31532f10b041f69ba325ed61797f7d
Source dataset
uspto-grants-2003_03
Patent number
US06534496B1

Reaction notes

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