Toluene → HCID 86758879, compound

Participants

Reaction Steps

7.5 g of (−)-cis-N-[2-(3,4-dimethoxyphenyl)cyclohexyl]-3,4-dinitrobenzamide (compound A1) are dissolved in 120 ml of acetonitrile or toluene and 3.5 ml of phosphorus oxychloride and the solution is stirred overnight at 80° C. The reaction mixture is concentrated under reduced pressure and the residue is extracted with satd. sodium hydrogencarbonate solution and ethyl acetate. The organic phases are dried using sodium sulfate and concentrated. The residue is recrystallized from ethyl acetate. M.p.: 162-165° C.

Provenance & Evidence