HCID 23433467, compound → HCID 22279055, compound

Participants

Reaction Steps

This compound was prepared from 6-tert-butyloxycarbamoyl-2-nitrotoluene (4.60 g, 18.2 mmol) in a manner similar to that described for 3-tert-butyloxycarbamoylaniline (EXAMPLE 13), affording 4.00 g (99%) of the desired aniline as a colorless oil. Data for 2-amino-6-tert-butyloxycarbamoyltoluene: 1H NMR (400 MHz, CDCl3) 7.04 and 6.81 (br δ of ABq, 2H, JAB=8.0 Hz, JA=0 Hz, JB=7.9 Hz, 4,5-H), 6.49 (d, 1H, J=8.3 Hz, 3-H), 6.26 (br s, 1H, NH), 3.61 (br s, 2H, NH2), 2.02 (s, 3H, 1-CH3), 1.51 [s, 9H, (CH3)3CO)].

Provenance & Evidence