HCID 22279055, compound → HCID 23433536, compound

Participants

Reaction Steps

This compound was prepared from 2-amino-6-tert-butyloxycarbamoyltoluene (4.00 g, 18.0 mmol) in a manner similar to that described for 7-tert-butyloxycarbamoyl-1,2-dihydro-2,2,4-trimethylquinoline (EXAMPLE 13), affording 4.56 g (84%) of the desired dihydroquinoline as a white solid. Data for 7-tert-butyloxycarbamoyl-1,2-dihydro-2,2,4,8-tetramethylquinoline: 1H NMR (400 MHz, CDCl3) 6.94 and 6.88 (br ABq, 2H, JAB·8.3 Hz, 6,5-H), 6.16 (br s, 1H, HNBoc), 5.27 (s, 1H, 3-H), 3.61 [br s, 1H, (CH3)2CNH], 2.04 (s, 3H, 8-CH3), 1.97 (s, 3H, 4-CH3), 1.50 [s, 9H, (CH3)3CO)], 1.28 [s, 6H, 2-(CH3)2].

Provenance & Evidence