Acetic Acid → 4-Benzyl-1-oxo-1lambda~5~-pyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-benzylpyridine (5 mL, 30 mmol), acetic acid (30 mL) and 30% hydrogen peroxide (10 mL) was heated at 80-90° C. for 5 h. Concentration under reduced pressure gave an oil that was diluted with NaHCO3 (100 mL) and extracted with CH2Cl2 (2×100 mL). The collected organic phase was washed with brine (100 mL) and evaporated in vacuo to give the title compound as a colorless oil (5.68 g, 98%): 1H NMR (DMSO-d6) δ3.90 (s, 2H), 7.15-7.35 (m, 7H), 8.08 (d, J=6.3 Hz, 2H).

Provenance & Evidence