Hydrochloric Acid → HCID 18621453, compound

Participants

Reaction Steps

To a solution of diethyl 2-((4-benzylpyridin-2-yl)methyl)malonate (2.6 g, 7.6 mmol) in EtOH (30 mL) were added PtO2 (70 mg) and conc. HCl (0.7 mL). The heterogeneous mixture was hydrogenated in a Parr hydrogenator at 30-35 psi at 25° C. for 16 h. The reaction was filtered through a Celite pad and was concentrated under reduced pressure to give the crude title compound as a yellow oil (3.0 g, 100%): 1H NMR (CDCl3) δ1.10-1.30 (m, 6H), 1.50-2.00 (m, 6H), 2.20-2.35 (m, 1H), 2.50-2.65 (m, 2H), 2.65-2.85 (m, 1H), 3.00-3.15 (m, 1H), 3.55-3.70 (m, JH), 3.90-4.05 (m, 1H), 4.05-4.30 (m, 4H), 7.08-7.32 (m, SH), 9.70 (bs, 2H) ; IR (film) 2927, 1735 cm−1.

Provenance & Evidence