反应详情

To a mixture of the compound (164 mg) obtained in Example 3 and acetonitrile (15 ml) was added methyl iodide (0.1 ml) and the reaction mixture was heated under reflux for 2 h. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent, chloroform methanol=95:5) to give 130 mg of the titled compound (yield, 54%).

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for 2 h
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe resulting residue was purified by silica gel column chromatography (eluent, chloroform methanol=95:5)