HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 136388339, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Tert-butyl 5-amino-2-methoxybenzylcarbamate | HCID 22981333 | — |
| Reactant | N-Nitro-S-methylisothiourea | HCID 135927615 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 136388339 | HCID 136388339 | 33% |
Reaction Steps
A mixture of the compound (130 mg) obtained in Example 119, triethylamine (0.09 ml), S-methyl-N-nitroisothiourea (84 mg), acetonitrile (3 ml) and methanol (1 ml) was heated under reflux for 20 h. The reaction mixture was distilled under reduced pressure and the residue was purified by silica gel column chromatography (eluent, chloroform:ethyl acetate=1:1) to give 57.2 mg of the titled compound (yield, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06534546B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-328f610d947645a4a0b69322f0c8c1e6 |
| Source note | uspto-grants-2003_03 |