HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → Methanesulfonic acid 8-(2-hydroxyacetylamino)naphthalen-2-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 1-(Chloroacetamido)-7-[(methanesulfonyl)oxy]naphthalene | HCID 15549325 | — |
| Solvent | Isopropyl Acetate | HCID 7915 | — |
| Product | Methanesulfonic acid 8-(2-hydroxyacetylamino)naphthalen-2-yl ester | HCID 88118569 | — |
Reaction Steps
To a solution of ester from Step B (11.0 g, 39.5 mmol) in 150 mL of i-PrOAc at room temperature was added ethanolamine (12.0 mL, 199 mmol). After 18 hours, the reaction was partitioned between EtOAc and water, and the organic layer was extracted with saturated brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide a dark oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06534506B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-fb6d84caeb864c26a6a86166673ff955 |
| Source note | uspto-grants-2003_03 |