Ethanol → HCID 18622557, compound

HRID 1862038Notes

Reaction equation

HRID 1862038 reaction equation
[C:1]1([C:7]2[C:8]3[C:18](=[O:19])[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[C:9]=3[NH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].C(O)C>O>[C:1]1([C:7]2[C:8]3[CH:18]([OH:19])[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[C:9]=3[NH:10][N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 3571921SBB062313HCID 4311764Sodium borohydride

Product 1

HCID 18622557HCID 18622557, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-phenylindeno[1,2-c]pyrazol-4(1H)-one (0.86 g), sodium borohydride (0.26 g) and absolute ethanol (200 ml) was stirred at ambient temperature for 72 hours. The mixture was filtered to remove a small amount of solid which was discarded and the filtrate was concentrated under reduced pressure to low volume whereupon crystals were formed. This suspension was diluted with water to approximately 250 ml and the solid was collected by filtration and recrystallized from methanol to give 3-phenyl-1,4-dihydroindeno[1,2-c]pyrazol-4-ol, m.p. 269-272° C.

Workup

  1. filtrationThe mixture was filtered
  2. customto remove a small amount of solid which
  3. concentrationthe filtrate was concentrated under reduced pressure to low volume whereupon crystals
  4. customwere formed
  5. filtrationthe solid was collected by filtration
  6. customrecrystallized from methanol

Sources & evidence

ORD record
ord-c3e8d42857e34f53924da82c9bb7b9a3
Source dataset
uspto-grants-2003_03
Patent number
US06534655B1

Reaction notes

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