Sulfuric Acid → HCID 70033087, compound

Participants

Reaction Steps

(R)-N-[5-Methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide (100 mg, 0.22 mmol) was dissolved in tetrahydrofuran (2 mL) by heating and sulfuric acid (25 mg, 0.24 mmol), dissolved in tetrahydrofuran (1 mL), was added dropwise. The white precipitate was filtered and washed with tetrahydrofuran to give 110 mg (89% yield). The crude salt (80 mg) was recrystallized from HBO (12 mL) and allowed to stand in the refrigerator over night. The solid was filtered and washed with cold H2O to give 28 mg (31% yield) a white solid: rmp 230° C. (decom.). Anal. Calcd. for C27H36N4O2xH2O4SxH2O: C, 57.4; H, 7.1; N, 9.9. Found: C, 57.7; H, 7.4; N, 9.9.

Provenance & Evidence