Gluconic Acid → HCID 70031375, compound

Participants

Reaction Steps

(R)-N-[5-Methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide (100 mg, 0.22 mmmol) was dissolved in ethanol (3 mL) and a 50% aqueous D-gluconic acid solution (80 μL, 0.24 mmol) was added dropwise. The solvent was removed in vacuo to give a white viscous oil. The crude oil was recrystallized from a 5% H2O in acetone solution (3 mL) and a 10% H2O in acetone solution (3 mL), decanted, then allowed to stand at room temperature for 65 h. The solid was filtered and washed with a cold 3% H2O in acetone solution to give 95 mg (65% yield) of a white solid: nip 130-140° C. Anal. Calcd. for C27H36N4O2xC6H12O7xH2O: C, 59.8; H, 7.6; N, 8.5. Found: C, 60.0; H, 7.4; N, 8.3.

Provenance & Evidence