1,2-Dibromoethane → HCID 86758885, compound

Participants

Reaction Steps

A solution of 3.3 g (59 mmol) of potassium hydroxide in 20 ml of methanol was added to a solution of 1.75 g (25 mmol) of hydroxylamine hydrochloride in 20 ml of methanol. The mixture was stirred at room temperature for 5 minutes, 4.5 g (12 mmol) of 5-methylhex-4-ene-2,3-dione 2-(O-(2-(methoxycarbonylmethoxyiminomethyl)benzyl)oxime) 3-(O-methyloxime) were then added and the mixture was stirred at 40° C. for 1 h. 1.8 g (13 mmol) of potassium carbonate and 5.1 ml (59 mmol) of 1,2-dibromoethane were subsequently added. The reaction mixture was stirred at room temperature for 18 h and then concentrated under reduced pressure, and the residue was purified by chromatography. This gave 0.6 g of the title compound as an oil.

Provenance & Evidence