HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[4-chloro-2-fluoro-5-{2-(methoxycarbonyl)methoxy-3-pyridyloxy}phenyl]tri fluoroacetoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Reactant | 4-Chloro-2-fluoro-5-{2-(methoxycarbonyl)methoxy-3-pyridyloxy}aniline | HCID 21933577 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[4-chloro-2-fluoro-5-{2-(methoxycarbonyl)methoxy-3-pyridyloxy}phenyl]tri fluoroacetoacetamide | HCID 86593477 | 100.5% |
Reaction Steps
A mixture of 0.50 g of 4-chloro-2-fluoro-5-{2-(methoxycarbonyl)methoxy-3-pyridyloxy}aniline, 0.28 g of ethyl trifluoroacetoacetate and 10 ml of toluene was subjected to azeotropic reaction with removing ethanol by passing through molecular sieves 5A for 3 hours. After cooling, the reaction solution was concentrated to obtain 0.71 g of N-[4-chloro-2-fluoro-5-{2-(methoxycarbonyl)methoxy-3-pyridyloxy}phenyl]trifluoroacetoacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06537948B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-b5a19b7f4a1b444cb7b1407b83d0291c |
| Source note | uspto-grants-2003_03 |