反应详情

1.65 g of 2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]benzenesulfonyl chloride was dissolved in 16 ml of acetic acid, to this was added 4.4 g of zinc, then, they were reacted while heating under reflux. After completion of the reaction, the reaction solution was cooled, then, this was poured into ice water, extracted with ethyl acetate, and filtrated. The filtrate was separated, then, the organic layer was washed with saturated saline, dried over anhydrous magnesium sulfate, and concentrated to obtain 1.35 g of 2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenyl mercaptan.

1. customthey were reacted
2. temperaturewhile heating
3. temperatureunder reflux
4. customAfter completion of the reaction
5. temperaturethe reaction solution was cooled
6. extractionextracted with ethyl acetate
7. filtrationfiltrated
8. customThe filtrate was separated
9. washthe organic layer was washed with saturated saline
10. dry with materialdried over anhydrous magnesium sulfate
11. concentrationconcentrated