Sodium hydride → HCID 18619157, compound

Participants

Reaction Steps

Sodium hydride is added to a mixture of 2,6-dichloro-3-nitropyridine, methyl glycolate and 1,4-dioxane at 10° C. The mixture is stirred at room temperature for 2 hours, then, poured into ice water, and extracted with ethyl acetate. The organic layer is dried over anhydrous magnesium sulfate, and concentrated. The residue is subjected to silica gel column chromatography to obtain 6-chloro-2-(methoxycarbonyl)methoxy-3-nitropyridine.

Provenance & Evidence