HCID 18619157, compound → HCID 18619164, compound

HRID 1862284Notes

Reaction equation

HRID 1862284 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:14]([O-])=O)=[CH:4][CH:3]=1>[Pt]=O.C(O)C>[NH2:14][C:5]1[C:6]([O:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

4

Reactant 1

HCID 18619157HCID 18619157, compound

Product 1

HCID 18619164HCID 18619164, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

A mixture of 6-chloro-2-(methoxycarbonyl)methoxy-3-nitropyridine, platinum oxide and ethanol is stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction system is purged with nitrogen, then, the reaction solution is filtrated through Celite, and the filtrate is concentrated. The residue is subjected to silica gel column chromatography to obtain 3-amino-6-chloro-2-(methoxycarbonyl)methoxypyridine.

Workup

  1. customThe reaction system is purged with nitrogen
  2. filtrationthe reaction solution is filtrated through Celite
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-2618b8a6bc7d4f00affb9b928a0265a6
Source dataset
uspto-grants-2003_03
Patent number
US06537948B1

Reaction notes

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