Dichloromethane → HCID 18619247, compound

Participants

Reaction Conditions

Reaction Steps

A boron trifluoride diethyl etherate is added to a mixture of 3-amino-6-chloro-2-(methoxycarbonyl)methoxypyridine, 1,2-dimethoxyethane and dichloromethane dropwise at −10° C. After mixing for 10 minutes at the same temperature, a solution of t-butyl nitrite in 1,2-dimethoxyethane is added to the reaction solution dropwise at −5° C. or lower. After mixing for 30 minutes at the same temperature, n-pentane is poured into the mixture. The lower layer of two separated layers is dissolved in acetic anhydride, and the mixture is stirred for 1 hour at 80° C. The solvent is distilled off, then, the resulted residue is subjected to silica gel chromatography to obtain 3-acetoxy-6-chloro-2-(methoxycarbonyl)methoxypyridine.

Provenance & Evidence