HCID 18619173, compound → HCID 18619201, compound

HRID 1862291Notes

Reaction equation

HRID 1862291 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[C:6]([N+:15]([O-])=O)=[CH:5][CH:4]=1>[Pt]=O.C(O)C>[NH2:15][C:6]1[C:7]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

Participants

4

Reactant 1

HCID 18619173HCID 18619173, compound

Product 1

HCID 18619201HCID 18619201, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

A mixture of 6-methoxy-2-(methoxycarbonyl)methoxy-3-nitropyridine, platinum oxide and ethanol is stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction system is purged with nitrogen, then, the reaction solution is filtrated through Celite, and the filtrate is concentrated. The residue is subjected to silica gel column chromatography to obtain 3-amino-6-methoxy-2-(methoxycarbonyl)methoxypyridine.

Workup

  1. customThe reaction system is purged with nitrogen
  2. filtrationthe reaction solution is filtrated through Celite
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-ab880a7d573e445aa1249f403dbcd990
Source dataset
uspto-grants-2003_03
Patent number
US06537948B1

Reaction notes

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