HCID 18619151, compound → HCID 178480551, compound

Participants

Reaction Steps

A solution of 2.5 g of crude product of 4-benzyloxy-3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-1,2,5-thiadiazole in 20 ml of trifluoroacetic acid was stirred over night at room temperature. The solution was concentrated, and the residue was subjected to silica gel column chromatography to obtain 0.50 g of 3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-4-hydroxy-1,2,5-thiadiazole.

Provenance & Evidence