3-Bromo-4-fluorobenzaldehyde → HCID 135532745, compound

HRID 1862361Notes

Reaction equation

HRID 1862361 reaction equation
[S:1]1(=[O:9])(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=O)[CH2:2]1.[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[F:19])[CH:14]=O.[NH2:20][C:21]1[CH:25]=[CH:24][NH:23][N:22]=1>C(O)C>[Br:10][C:11]1[CH:12]=[C:13]([CH:14]2[N:22]3[N:23]=[CH:24][CH:25]=[C:21]3[NH:20][C:3]3[CH2:4][CH2:5][CH2:6][S:1](=[O:9])(=[O:8])[C:2]2=3)[CH:16]=[CH:17][C:18]=1[F:19]

Participants

5

Reactant 3

HCID 1736043-Bromo-4-fluorobenzaldehydeHCID 11815935Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxideHCID 178418806HCID 178418806, compound

Product 1

HCID 135532745HCID 135532745, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of tetrahydrothiopyran-3-one-1,1-dioxide (0.74 g, 5 mmol), 3-bromo-4-fluorobenzaldehyde (1.01 g, 5 mmol), and 3-aminopyrazole (0.41 g, 5 mmol) in ethanol (5 mL) was heated at reflux for 24 hours. After the reaction mixture was allowed to cool to ambient temperature, the solid that precipitated was filtered off, washed with ethanol, and dried to provide the title compound.

Workup

  1. temperatureat reflux for 24 hours
  2. customthe solid that precipitated
  3. filtrationwas filtered off
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-139d012e0b234578b1d9b4a35735c6dd
Source dataset
uspto-grants-2003_03
Patent number
US06538000B1

Reaction notes

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