1,3-Cyclopentanedione → HCID 10224229, compound

HRID 1862417Notes

Reaction equation

HRID 1862417 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[I:10].[CH2:11]1[C:16](=O)[CH2:15][C:13](=[O:14])[CH2:12]1.[NH2:18][C:19]1[N:23]([CH3:24])[NH:22][C:21](=[O:25])[CH:20]=1>>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]2[C:20]3[C:21](=[O:25])[NH:22][N:23]([CH3:24])[C:19]=3[NH:18][C:16]3[CH2:11][CH2:12][C:13](=[O:14])[C:15]2=3)=[CH:4][C:3]=1[I:10]

Participants

4

Reactant 3

HCID 774661,3-CyclopentanedioneHCID 2521985-amino-1-methyl-2,3-dihydro-1H-pyrazol-3-oneHCID 103080734-Fluoro-3-iodobenzaldehyde

Product 1

HCID 10224229HCID 10224229, compoundYield 63.5%

Procedure

4-Fluoro-3-iodobenzaldehyde (0.25 g, 1.0 mmol) from Example 12C, 1,3 cyclopentadione (0.1 g, 1.0 mmol) and 5-amino-1-methyl-1,2-dihydropyrazol-3-one (0.11 g, 1.0 mmol) were processed as described in Example 1 to provide 0.27 g of the title compound.

Sources & evidence

ORD record
ord-6b517dc3e3ae4eba809fef1fd75602cd
Source dataset
uspto-grants-2003_03
Patent number
US06538004B2

Reaction notes

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