Methanol → Z-D-Dap-OMe.HCl

Participants

Reaction Steps

Thionyl chloride (3.22 ml) was added dropwise to methanol (25 ml) at 4° C. under a nitrogen atmosphere. After stirred for 30 minutes, to the reaction mixture was added 2(R)-benzyloxycarbonylamino-β-alanine (3 g), followed by warming to the ambient temperature and stirring overnight. The insoluble material was collected by filtration, washed with diisopropyl ether, and dried under a reduced pressure to give 2(R) -benzyloxycarbonylamino-β-alanine methyl ester hydrochloride (3.15 g) as a white solid.

Provenance & Evidence