HCID 10900116, compound → HCID 54503490, compound

Participants

Reaction Steps

Added 5% Pd/C, 50% H2O catalyst (94.0 mg, 22.1 μmol) to a solution of (1-cyanocyclohexa-2,5-dienyl)acetic acid t-butyl ester (0.50 g, 2.3 mmol) in MeOH (10 mL). After shaking the reaction mixture under 20 psi H2 at room temperature for 18.5 hours, the pressure was slowly released. The reaction was filtered and concentrated under reduced pressure. Flash chromatography (SiO2, 1:3 hexane:CH2Cl2-100% CH2Cl2) afforded 0.29 g (56%) of product as an oil.

Provenance & Evidence