HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 4-(methanesulfonamidomethyl)-2-sulfamoylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 2-(chlorosulfonyl)-4-[[(methylsulfonyl)amino]methyl]benzoate | HCID 22494947 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4-(methanesulfonamidomethyl)-2-sulfamoylbenzoate | HCID 17937780 | 80.5% |
Reaction Steps
A solution of 11 g (32 mmol) of methyl 2-chlorosulfonyl-4-methanesulfonylaminomethylbenzoate in 200 ml of THF is treated at 0° C. with 1.1 g (64 mmol) of NH3 gas. For work-up, the mixture is concentrated in vacuo. Extracting the residue by stirring with water and then filtration and drying in vacuo give 8.3 g (80%) of methyl 2-sulfamoyl-4-methanesulfonylaminomethylbenzoate of melting point 185-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06538150B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-3dcfd583630c4fe59de13c5130b10bcd |
| Source note | uspto-grants-2003_03 |