HCID 18620167, compound → HCID 18620145, compound

Participants

Reaction Steps

To a solution of 2′-benzyloxy-5′-(2-bromoethyl)formanilide (510 mg) in methanol (8 ml) was added 10% palladium carbon (wet, 50% water) (100 mg), and the mixture was stirred for 45 minutes at room temperature under a hydrogen atmosphere. The catalyst was filtered off, and the solvent of the filtrate was removed under reduced pressure. Purification of the residue by flash column chromatography on silica gel (eluent:methanol/dichloromethane/diethyl ether=1/10/10) gave 5′-(2-bromoethyl)-2′-hydroxyformanilide (339 mg).

Provenance & Evidence