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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1862623Generated: November 1, 2026

2-Benzyloxy-5-[2-(p-toluenesulfonyloxy)ethyl]benzamide → Benzamide

https://huagongshe.com/reaction/1862623

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Benzyloxy-5-[2-(p-toluenesulfonyloxy)ethyl]benzamideHCID 18620113—
CatalystHCID 178418390HCID 178418390—
SolventMethanolHCID 887—
SolventTetrahydrofuranHCID 8028—
ProductBenzamideHCID 2331260.5%

Reaction Steps

2-Benzyloxy-5-[2-(p-toluenesulfonyloxy)ethyl]benzamide (627 mg) was dissolved in methanol (5 ml) and tetrahydrofuran (5 ml), and 10% palladium carbon (wet, 50% water) (169 mg) was added to the solution. The mixture was stirred for 1 hour at room temperature under a hydrogen atmosphere, and the catalyst was filtered off. Removal of the solvent under reduced pressure gave 2-hydroxy-5-[2-toluenesulfonyloxy)ethyl]benzamide (465 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06538152B1
Source datasetuspto-grants-2003_03
ORD IDord-dc26481754074cf99fd4dc34845ef5ad
Source noteuspto-grants-2003_03