HCID 15895330, compound → HCID 15895331, compound

Participants

Reaction Steps

To a solution of 2-[2-benzyloxy-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid (97 mg) in acetic acid (4 ml) was added 10% palladium carbon (wet, 50% water) (30 mg), and the mixture was stirred for 50 minutes at room temperature under a hydrogen atmosphere. The catalyst was filtered off, and the solvent was removed under reduced pressure. After addition of ethyl acetate to the residue, collection of the resulting insoluble material by filtration gave 2-[2-hydroxy-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid (77 mg).

Provenance & Evidence