Hydrochloric Acid → HCID 69904942, compound

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Reaction Steps

To a stirred solution of ethyl 2-[2-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate (390 mg) in ethyl acetate (5 ml) was added 4N hydrogen chloride solution in ethyl acetate (500 μl) at room temperature, and the mixture was stirred for 15 minutes. After removal of the solvent under reduced pressure, diethyl ether was added to the residue. Collection of the resulting insoluble material by filtration gave ethyl 2-[2-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate hydrochloride (400 mg).

Provenance & Evidence