HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-[3-Methoxy-4-(3-phenyl-propoxy)-phenyl]-ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | [3-Methoxy-4-(3-phenyl-prop-2-ynyloxy)-phenyl]-acetonitrile | HCID 18619867 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[3-Methoxy-4-(3-phenyl-propoxy)-phenyl]-ethylamine | HCID 18620194 | — |
Reaction Steps
A mixture of [3-methoxy-4-(3-phenyl-prop-2-ynyloxy)-phenyl]-acetonitrile (2.0 g), liquid ammonia (5 g) and Raney-nickel (1 g) in methanol (100 ml) is shaken in an autoclave under hydrogen (100 bar) at +70° C. for 2 hours. The reaction mixture is filtered and evaporated. 2-[3-Methoxy-4-(3-phenyl-propoxy)-phenyl]-ethylamine is obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06538159B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-b52a415ee6d844c98cf5d47f5f538a9a |
| Source note | uspto-grants-2003_03 |