Methanesulfonyl chloride → HCID 22982654, compound

HRID 1862718Notes

Reaction equation

[CH3:1][N:2]([C@@H:10]1[CH2:14][C@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C@@H:12]([CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([CH2:28][CH2:29][CH2:30][C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)[CH2:24][CH2:23]2)[CH2:11]1)C(OC(C)(C)C)=O.[CH3:38][S:39](Cl)(=[O:41])=[O:40]>>[CH3:1][N:2]([C@@H:10]1[CH2:14][C@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C@@H:12]([CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([CH2:28][CH2:29][CH2:30][C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)[CH2:24][CH2:23]2)[CH2:11]1)[S:39]([CH3:38])(=[O:41])=[O:40]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 22982657HCID 22982657, compound

Product 1

HCID 22982654HCID 22982654, compound

Procedure

Using essentially the same procedure as in Example 16, Step A and B but substituting 1-(R)-(N-(methyl)-N-(t-butoxycarbonyl)amino)-3-(S)-((4-(3-(4-fluorophenyl)prop-1-yl)piperidin-1-yl)methyl)-4-(S)-phenylcyclopentane from Example 26, Step H in Step A and methylsulfonyl chloride in Step B, the title compound can be prepared.

Sources & evidence

ORD record: ord-26ead089e65d4b85ae3e9850bb8693f6
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06538002B1

Reaction notes

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