Methanesulfonyl chloride → HCID 22982665, compound

HRID 1862720Notes

Reaction equation

C(OC([NH:8][C@H:9]1[CH2:13][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@@H:11]([CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([CH2:27][CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH2:23][CH2:22]2)[CH2:10]1)=O)(C)(C)C.[CH3:37][S:38](Cl)(=[O:40])=[O:39]>>[CH3:37][S:38]([NH:8][C@H:9]1[CH2:13][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@@H:11]([CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([CH2:27][CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH2:23][CH2:22]2)[CH2:10]1)(=[O:40])=[O:39]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 22982674HCID 22982674, compound

Product 1

HCID 22982665HCID 22982665, compound

Procedure

Using essentially the same procedure as in Example 16, Step A and B but substituting 1-(S)-(N-(t-butoxycarbonyl)amino)-3-(S)-((4-(3-(4-fluorophenyl)prop-1-yl)piperidin-1-yl)methyl)-4-(S)-phenylcyclopentane from Example 30 in Step A and methylsulfonyl chloride in Step B, the title compound can be prepared.

Sources & evidence

ORD record: ord-09e34d4dd2974a27b6262d746b9ccbd2
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06538002B1

Reaction notes

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