HCID 12045563, compound → HCID 12045566, compound

HRID 1862763Notes

Reaction equation

HRID 1862763 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[C:16]([N+:17]([O-:19])=[O:18])=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:6][CH:5]=1.C([Si]([O:37][C:38]1[CH:43]=[CH:42][C:41]([O:44][CH2:45][CH:46]2[CH2:48][O:47]2)=[CH:40][CH:39]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[OH:47][C@@H:46]([CH2:48][NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[C:16]([N+:17]([O-:19])=[O:18])=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:6][CH:5]=1)[CH2:45][O:44][C:41]1[CH:42]=[CH:43][C:38]([OH:37])=[CH:39][CH:40]=1

Participants

4

Reactant 2

HCID 12045563HCID 12045563, compoundHCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane

Product 1

HCID 12045566HCID 12045566, compoundYield 6.3%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-[4-(2-Aminoethyl)phenyl]-3-nitro-2-pyridinamine (0.87 g, 3.37 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (1.36 g, 3.36 mmol) according to Procedure G (eluant: 20:1 going to 5:1 chloroform-methanol) to give the title compound (0.59 g, 0.21 mmol).

Sources & evidence

ORD record
ord-23866512b3eb41768f758d468da111ea
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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