HCID 12045565, compound → HCID 12045566, compound

HRID 1862764Notes

Reaction equation

HRID 1862764 reaction equation
[Si]([O:18][C:19]1[CH:48]=[CH:47][C:22]([O:23][CH2:24][C@@H:25]([OH:46])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([NH:36][C:37]3[C:42]([N+:43]([O-:45])=[O:44])=[CH:41][CH:40]=[CH:39][N:38]=3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl>[OH:46][C@@H:25]([CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([NH:36][C:37]2[C:42]([N+:43]([O-:45])=[O:44])=[CH:41][CH:40]=[CH:39][N:38]=2)=[CH:32][CH:31]=1)[CH2:24][O:23][C:22]1[CH:47]=[CH:48][C:19]([OH:18])=[CH:20][CH:21]=1

Participants

3

Reactant 1

HCID 12045565HCID 12045565, compound

Product 1

HCID 12045566HCID 12045566, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

(2S)-1-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-3-({4-[(3-nitro-2-pyridinyl)amino]phenethyl}amino)-2-propanol (0.06 g, 0.09 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform) to give the title compound (0.03 g, 0.07 mmol).

Sources & evidence

ORD record
ord-2d446d43daa8410a81c45651d7be291e
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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