Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10165003, compound

HRID 1862766Notes

Reaction equation

HRID 1862766 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:29]=[CH:28][C:10]([NH:11][C:12]2[C:17]([NH:18][C:19]([NH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:20])=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:9][CH:8]=1.C([Si]([O:47][C:48]1[CH:53]=[CH:52][C:51]([O:54][CH2:55][CH:56]2[CH2:58][O:57]2)=[CH:50][CH:49]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH2:22]([NH:21][C:19]([NH:18][C:17]1[C:12]([NH:11][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:58][C@H:56]([OH:57])[CH2:55][O:54][C:51]3[CH:52]=[CH:53][C:48]([OH:47])=[CH:49][CH:50]=3)=[CH:29][CH:28]=2)=[N:13][CH:14]=[CH:15][CH:16]=1)=[O:20])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 70006350HCID 70006350, compound

Product 1

HCID 10165003HCID 10165003, compoundYield 32.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-{2-[4-(2-Aminoethyl)anilino]-3-pyridinyl}-N′-hexylurea formate (0.24 g, 0.60 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.242 g, 0.60 mmol) according to Procedure G (eluant: 20:1 going to 10:1 chloroform-methanol) to give the title compound (0.15 g, 0.197 mmol).

Sources & evidence

ORD record
ord-f163e6e98cd9491cb34e59d9cfe59c5b
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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