HCID 70008641, compound → HCID 10163864, compound

HRID 1862769Notes

Reaction equation

HRID 1862769 reaction equation
[Si]([O:18][C:19]1[CH:54]=[CH:53][C:22]([O:23][CH2:24][C@@H:25]([OH:52])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:51]=[CH:50][C:33]([NH:34][C:35]3[C:40]([NH:41][C:42](=[O:49])[C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)=[CH:39][CH:38]=[CH:37][N:36]=3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[OH:52][C@H:25]([CH2:24][O:23][C:22]1[CH:21]=[CH:20][C:19]([OH:18])=[CH:54][CH:53]=1)[CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:51]=[CH:50][C:33]([NH:34][C:35]2[C:40]([NH:41][C:42](=[O:49])[C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)=[CH:39][CH:38]=[CH:37][N:36]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 1

HCID 70008641HCID 70008641, compound

Product 1

HCID 10163864HCID 10163864, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-{2-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-3-pyridinyl}benzamide (0.064 g, 0.087 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.039 g, 0.078 mmol).

Sources & evidence

ORD record
ord-ca41909fb331487c925000a3e4010e02
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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