Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10207643, compound

HRID 1862772Notes

Reaction equation

HRID 1862772 reaction equation
C(O)=O.[CH2:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][NH2:29])=[CH:23][CH:22]=3)[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:14]3[N:13]=2)=[CH:8][CH:7]=1)[CH3:5].C([Si]([O:47][C:48]1[CH:53]=[CH:52][C:51]([O:54][CH2:55][CH:56]2[CH2:58][O:57]2)=[CH:50][CH:49]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH2:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[N:20]([C:21]3[CH:22]=[CH:23][C:24]([CH2:27][CH2:28][NH:29][CH2:58][C@H:56]([OH:57])[CH2:55][O:54][C:51]4[CH:52]=[CH:53][C:48]([OH:47])=[CH:49][CH:50]=4)=[CH:25][CH:26]=3)[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:14]3[N:13]=2)=[CH:10][CH:11]=1)[CH3:5]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619630HCID 18619630, compound

Product 1

HCID 10207643HCID 10207643, compoundYield 34.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

2-{4-[2-(4-Ethylphenyl)-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}-1-ethanamine formate (0.27 g, 0.746 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.2 g, 0.5 mmol) according to Procedure G (eluant: 20:1 going to 5:1 chloroform-methanol) to give the title compound (0.13 g, 0.174 mmol).

Sources & evidence

ORD record
ord-b0777aa1e3a24f07b1016fffd525d221
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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