Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 18619640, compound

HRID 1862782Notes

Reaction equation

HRID 1862782 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=[C:14]2[C:22]2[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])=[O:30])[CH:25]=[CH:26][CH:27]=2)=[CH:9][CH:8]=1.C([Si]([O:55][C:56]1[CH:61]=[CH:60][C:59]([O:62][CH2:63][CH:64]2[CH2:66][O:65]2)=[CH:58][CH:57]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH2:32]([NH:31][C:29]([NH:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:22]([C:14]2[N:13]([C:10]3[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][NH:4][CH2:66][CH:64]([OH:65])[CH2:63][O:62][C:59]4[CH:60]=[CH:61][C:56]([OH:55])=[CH:57][CH:58]=4)=[CH:8][CH:9]=3)[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=2)[CH:23]=1)=[O:30])[CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619617HCID 18619617, compound

Product 1

HCID 18619640HCID 18619640, compoundYield 40.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-(3-{3-[4-(2-aminoethyl)phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N′-hexylurea formate (0.27 g, 0.539 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.217 g, 0.54 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.19 g, 0.22 mmol).

Sources & evidence

ORD record
ord-5023752f1b9b4dd381133fc618467548
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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