Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 70007134, compound

HRID 1862784Notes

Reaction equation

HRID 1862784 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=[C:14]2[CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[O:32])=[CH:26][CH:25]=2)=[CH:9][CH:8]=1.C([Si]([O:57][C:58]1[CH:63]=[CH:62][C:61]([O:64][CH2:65][CH:66]2[CH2:68][O:67]2)=[CH:60][CH:59]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH2:34]([NH:33][C:31]([NH:30][C:27]1[CH:26]=[CH:25][C:24]([CH2:23][CH2:22][C:14]2[N:13]([C:10]3[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][NH:4][CH2:68][C@H:66]([OH:67])[CH2:65][O:64][C:61]4[CH:62]=[CH:63][C:58]([OH:57])=[CH:59][CH:60]=4)=[CH:8][CH:9]=3)[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=2)=[CH:29][CH:28]=1)=[O:32])[CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18619634HCID 18619634, compound

Product 1

HCID 70007134HCID 70007134, compoundYield 35.5%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-[4-(2-{3-[4-(2-Aminoethyl)phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}ethyl)phenyl]-N′-hexylurea formate (0.541 g, 1.03 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.250 g, 0.619 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.195 g, 0.220 mmol).

Sources & evidence

ORD record
ord-592a333b36a14d14917b7e09ef8b961c
Source dataset
uspto-grants-2003_03
Patent number
US06537994B2

Reaction notes

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