反应详情

A mixture consisting of 5.6 g of 3-chloro-4-isopropoxyaniline, 3.9 g of methyl 1-methoxycyclopropanecarboxylate and 1.8 g of sodium methoxide in 50 ml of benzene was refluxed for 3 hours. The reaction mixture was concentrated to a volume of 25 ml, poured over ice water, acidified with hydrochloric acid and extracted with ether. The extract was dried, filtered and concentrated. Purification by silica chromatography gave 1.8 g of product as a white crystalline solid; m.p. 86°-87° C.

1. temperaturewas refluxed for 3 hours
2. concentrationThe reaction mixture was concentrated to a volume of 25 ml
3. additionpoured over ice water
4. extractionextracted with ether
5. customThe extract was dried
6. filtrationfiltered
7. concentrationconcentrated
8. customPurification by silica chromatography