反应详情

A mixture of 2.6 g of 4-methoxy-o-phenylenediamine hydrochloride, 70 ml of ethanol, 15 ml of carbon disulfide and an aqueous solution containing 1.5 g of sodium hydroxide and 5 ml of water was refluxed for 4 hours. Then, the reaction mixture was condensed under reduced pressure. The residue was recrystallized from a mixture of water and methanol (70:30 by volume) to obtain 1.3 g of 2-mercapto-5-methoxybenzimidazole (Compound (III-15)) having a melting point of 254° to 255° C. (yield: 59%).

1. temperaturewas refluxed for 4 hours
2. customcondensed under reduced pressure
3. customThe residue was recrystallized from a mixture of water and methanol (70:30 by volume)