Acetic Anhydride → N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

HRID 1862829Notes

Reaction equation

HRID 1862829 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[O:10])[CH:5]([CH3:9])[C:6](=[O:8])[N:7]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(O)(=O)C>[C:11]([NH:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]([CH3:9])[C:4](=[O:10])[N:3]=1)(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 272472655477-35-5

Product 1

HCID 20393810N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

80 parts of 2-amino-4,6-dioxo-5-methyl-pyrimidine are treated for 8 hours under reflux in a mixture comprising 500 parts by volume of acetic acid and 108 parts by volume of acetic anhydride. 87 parts of the desired product are obtained by filtration, washing with ether and drying in vacuo.

Sources & evidence

ORD record
ord-d6c4d46621f341e6a7072144e29143c3
Source dataset
uspto-grants-1979_09
Patent number
US04166852

Reaction notes

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