Pyridine → 3,5-Dioxohexanoic acid

Participants

Reaction Steps

5 g. of catechin acetonide were dissolved in 25 ml. of pyridine and 25 ml. of acetic anhydride added to the solution which was then left to react overnight at room temperature. The reaction mixture was subsequently poured with mechanical agitation into 500 ml. of water at 4°-5° C. The obtained precipitate was filtered and washed with water to neutrality. On crystallisation from a mixture of isopropanol and water, 5 g. of triacetate of catechin acetonide were obtained. The product melted at 120°-122° C. (Found: C, 63.12; H, 5.30; C24H24O9 requires: C, 63.16; H, 5.26).

Provenance & Evidence