HCID 20393036, compound → HCID 20393027, compound

Participants

Reaction Steps

14 gm of the end product of step (a) were hydrogenated in 400 ml of methanol in the presence of 5 gm of 10% palladium-on-charcoal at 50° C. and 50 atmospheres. After separating the catalyst, the reaction mixture was evaporated in vacuo, and the residue was purified on a silica gel column. Then, the product was recrystallized from petroleum ether (b.p. 100°-140° C.), yielding 42% of theory of 11-(3-ethylamino-propyl)-6,11-dihydro-2,4,6-trimethyl-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one which had a m.p. of 101°-103° C.

Provenance & Evidence