Beta-Alanine → HCID 20392989, compound

Participants

Reaction Steps

4-Chloro-3-nitrobenzophenone (10 g.) was added to a mixture of 3-aminopropionic acid (β-alanine) (10.1 g.) and sodium hydrogen carbonate (9.6 g.) in 2-methoxyethanol (100 ml.) which was then heated under reflux for 4 hours. The mixture was cooled, poured into ice-water (250 ml.) and brought to pH 3 by addition of concentrated hydrochloric acid. The solid obtained was filtered, washed with water and air-dried to give 3-(4-benzoyl-2-nitroanilino)propionic acid (12.1 g), m.p. 170°-5° C.

Provenance & Evidence