HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzenesulfonyl chloride → Piperazine, 1-((4-methoxyphenyl)sulfonyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| Reactant | 1-Piperazinyl(4-((7-(trifluoromethyl)-4-quinolinyl)amino)phenyl)methanone | HCID 3055243 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Piperazine, 1-((4-methoxyphenyl)sulfonyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl)- | HCID 453429 | 53% |
Reaction Steps
In the manner given in Example 15, 4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine is reacted with 4-methoxyphenylsulfonyl chloride, in the presence of triethylamine to give 1-[(4-methoxyphenyl)sulfonyl]-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine of melting point 221°-223° C. in a 53% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04167567 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-9bdb41d9548845c0bba0abaaff6ba96b |
| Source note | uspto-grants-1979_09 |